Review



global methylation inhibitor  (TargetMol)


Bioz Verified Symbol TargetMol is a verified supplier
Bioz Manufacturer Symbol TargetMol manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 93
      Buy from Supplier

    Structured Review

    TargetMol global methylation inhibitor
    The protein expression of MEF2C is regulated by m6A modification. (A,B) MEF2C and FTO protein levels after FTO knockdown and overexpression on the 4th day after differentiation. (C,D) MEF2C and METTL3 protein levels after METTL3 knockdown and overexpression for 4th day post differentiation. (E,F) Treatment with a global <t>methylation</t> inhibitor, 3-Deazaadenosine (DAA), for 24 and 48 h led to the downregulation of the MEF2C protein levels in bovine skeletal myoblasts. The results are presented as the means ± SD (* p < 0.05, ** p < 0.01, *** p < 0.001, siNC vs. siRNA samples and DMSO vs. DAA at 24h; # p < 0.05, # # # p < 0.001, empty vector vs. overexpression plasmid samples and DMSO vs. DAA at 48h), using Student's t test.
    Global Methylation Inhibitor, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/global methylation inhibitor/product/TargetMol
    Average 93 stars, based on 9 article reviews
    global methylation inhibitor - by Bioz Stars, 2026-03
    93/100 stars

    Images

    1) Product Images from "MEF2C Expression Is Regulated by the Post-transcriptional Activation of the METTL3-m 6 A-YTHDF1 Axis in Myoblast Differentiation"

    Article Title: MEF2C Expression Is Regulated by the Post-transcriptional Activation of the METTL3-m 6 A-YTHDF1 Axis in Myoblast Differentiation

    Journal: Frontiers in Veterinary Science

    doi: 10.3389/fvets.2022.900924

    The protein expression of MEF2C is regulated by m6A modification. (A,B) MEF2C and FTO protein levels after FTO knockdown and overexpression on the 4th day after differentiation. (C,D) MEF2C and METTL3 protein levels after METTL3 knockdown and overexpression for 4th day post differentiation. (E,F) Treatment with a global methylation inhibitor, 3-Deazaadenosine (DAA), for 24 and 48 h led to the downregulation of the MEF2C protein levels in bovine skeletal myoblasts. The results are presented as the means ± SD (* p < 0.05, ** p < 0.01, *** p < 0.001, siNC vs. siRNA samples and DMSO vs. DAA at 24h; # p < 0.05, # # # p < 0.001, empty vector vs. overexpression plasmid samples and DMSO vs. DAA at 48h), using Student's t test.
    Figure Legend Snippet: The protein expression of MEF2C is regulated by m6A modification. (A,B) MEF2C and FTO protein levels after FTO knockdown and overexpression on the 4th day after differentiation. (C,D) MEF2C and METTL3 protein levels after METTL3 knockdown and overexpression for 4th day post differentiation. (E,F) Treatment with a global methylation inhibitor, 3-Deazaadenosine (DAA), for 24 and 48 h led to the downregulation of the MEF2C protein levels in bovine skeletal myoblasts. The results are presented as the means ± SD (* p < 0.05, ** p < 0.01, *** p < 0.001, siNC vs. siRNA samples and DMSO vs. DAA at 24h; # p < 0.05, # # # p < 0.001, empty vector vs. overexpression plasmid samples and DMSO vs. DAA at 48h), using Student's t test.

    Techniques Used: Expressing, Modification, Knockdown, Over Expression, Methylation, Plasmid Preparation

    MEF2C promotes the differentiation of bovine myoblasts by posttranscriptional activation of the METTL3-m 6 A-YTHDF1 axis. METTL3 catalyzes the N 6 -methylation of MEF2C mRNA, and YTHDF1 recognizes this modification site to promote the translation of MEF2C. Then, MEF2C can directly bind to the promoter region of METTL3 to activate its expression, suggesting that there is a positive feedback loop underlying the process of bovine skeletal myoblast differentiation.
    Figure Legend Snippet: MEF2C promotes the differentiation of bovine myoblasts by posttranscriptional activation of the METTL3-m 6 A-YTHDF1 axis. METTL3 catalyzes the N 6 -methylation of MEF2C mRNA, and YTHDF1 recognizes this modification site to promote the translation of MEF2C. Then, MEF2C can directly bind to the promoter region of METTL3 to activate its expression, suggesting that there is a positive feedback loop underlying the process of bovine skeletal myoblast differentiation.

    Techniques Used: Activation Assay, Methylation, Modification, Expressing



    Similar Products

    global methylation inhibitor  (TargetMol)
    93
    TargetMol global methylation inhibitor
    The protein expression of MEF2C is regulated by m6A modification. (A,B) MEF2C and FTO protein levels after FTO knockdown and overexpression on the 4th day after differentiation. (C,D) MEF2C and METTL3 protein levels after METTL3 knockdown and overexpression for 4th day post differentiation. (E,F) Treatment with a global <t>methylation</t> inhibitor, 3-Deazaadenosine (DAA), for 24 and 48 h led to the downregulation of the MEF2C protein levels in bovine skeletal myoblasts. The results are presented as the means ± SD (* p < 0.05, ** p < 0.01, *** p < 0.001, siNC vs. siRNA samples and DMSO vs. DAA at 24h; # p < 0.05, # # # p < 0.001, empty vector vs. overexpression plasmid samples and DMSO vs. DAA at 48h), using Student's t test.
    Global Methylation Inhibitor, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/global methylation inhibitor/product/TargetMol
    Average 93 stars, based on 1 article reviews
    global methylation inhibitor - by Bioz Stars, 2026-03
    93/100 stars
    		  Buy from Supplier
    global methylation inhibitors 3-deazaadenosine b6121  (ApexBio)
    90
    ApexBio global methylation inhibitors 3-deazaadenosine b6121
    The protein expression of MEF2C is regulated by m6A modification. (A,B) MEF2C and FTO protein levels after FTO knockdown and overexpression on the 4th day after differentiation. (C,D) MEF2C and METTL3 protein levels after METTL3 knockdown and overexpression for 4th day post differentiation. (E,F) Treatment with a global <t>methylation</t> inhibitor, 3-Deazaadenosine (DAA), for 24 and 48 h led to the downregulation of the MEF2C protein levels in bovine skeletal myoblasts. The results are presented as the means ± SD (* p < 0.05, ** p < 0.01, *** p < 0.001, siNC vs. siRNA samples and DMSO vs. DAA at 24h; # p < 0.05, # # # p < 0.001, empty vector vs. overexpression plasmid samples and DMSO vs. DAA at 48h), using Student's t test.
    Global Methylation Inhibitors 3 Deazaadenosine B6121, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/global methylation inhibitors 3-deazaadenosine b6121/product/ApexBio
    Average 90 stars, based on 1 article reviews
    global methylation inhibitors 3-deazaadenosine b6121 - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    The protein expression of MEF2C is regulated by m6A modification. (A,B) MEF2C and FTO protein levels after FTO knockdown and overexpression on the 4th day after differentiation. (C,D) MEF2C and METTL3 protein levels after METTL3 knockdown and overexpression for 4th day post differentiation. (E,F) Treatment with a global methylation inhibitor, 3-Deazaadenosine (DAA), for 24 and 48 h led to the downregulation of the MEF2C protein levels in bovine skeletal myoblasts. The results are presented as the means ± SD (* p < 0.05, ** p < 0.01, *** p < 0.001, siNC vs. siRNA samples and DMSO vs. DAA at 24h; # p < 0.05, # # # p < 0.001, empty vector vs. overexpression plasmid samples and DMSO vs. DAA at 48h), using Student's t test.

    Journal: Frontiers in Veterinary Science

    Article Title: MEF2C Expression Is Regulated by the Post-transcriptional Activation of the METTL3-m 6 A-YTHDF1 Axis in Myoblast Differentiation

    doi: 10.3389/fvets.2022.900924

    Figure Lengend Snippet: The protein expression of MEF2C is regulated by m6A modification. (A,B) MEF2C and FTO protein levels after FTO knockdown and overexpression on the 4th day after differentiation. (C,D) MEF2C and METTL3 protein levels after METTL3 knockdown and overexpression for 4th day post differentiation. (E,F) Treatment with a global methylation inhibitor, 3-Deazaadenosine (DAA), for 24 and 48 h led to the downregulation of the MEF2C protein levels in bovine skeletal myoblasts. The results are presented as the means ± SD (* p < 0.05, ** p < 0.01, *** p < 0.001, siNC vs. siRNA samples and DMSO vs. DAA at 24h; # p < 0.05, # # # p < 0.001, empty vector vs. overexpression plasmid samples and DMSO vs. DAA at 48h), using Student's t test.

    Article Snippet: Additionally, MEF2C protein level was substantially decreased after 24 and 48 h of treatment with a global methylation inhibitor, 3-deazaadenosine (DAA) (4 μM, 86583-19-9, TargetMOI, MA, USA), without affecting its mRNA expression ( , ).

    Techniques: Expressing, Modification, Knockdown, Over Expression, Methylation, Plasmid Preparation

    MEF2C promotes the differentiation of bovine myoblasts by posttranscriptional activation of the METTL3-m 6 A-YTHDF1 axis. METTL3 catalyzes the N 6 -methylation of MEF2C mRNA, and YTHDF1 recognizes this modification site to promote the translation of MEF2C. Then, MEF2C can directly bind to the promoter region of METTL3 to activate its expression, suggesting that there is a positive feedback loop underlying the process of bovine skeletal myoblast differentiation.

    Journal: Frontiers in Veterinary Science

    Article Title: MEF2C Expression Is Regulated by the Post-transcriptional Activation of the METTL3-m 6 A-YTHDF1 Axis in Myoblast Differentiation

    doi: 10.3389/fvets.2022.900924

    Figure Lengend Snippet: MEF2C promotes the differentiation of bovine myoblasts by posttranscriptional activation of the METTL3-m 6 A-YTHDF1 axis. METTL3 catalyzes the N 6 -methylation of MEF2C mRNA, and YTHDF1 recognizes this modification site to promote the translation of MEF2C. Then, MEF2C can directly bind to the promoter region of METTL3 to activate its expression, suggesting that there is a positive feedback loop underlying the process of bovine skeletal myoblast differentiation.

    Article Snippet: Additionally, MEF2C protein level was substantially decreased after 24 and 48 h of treatment with a global methylation inhibitor, 3-deazaadenosine (DAA) (4 μM, 86583-19-9, TargetMOI, MA, USA), without affecting its mRNA expression ( , ).

    Techniques: Activation Assay, Methylation, Modification, Expressing